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KMID : 0613319960020010072
Journal of the Korean Bone and Joint Tumor Soceity
1996 Volume.2 No. 1 p.72 ~ p.77
Effect and Tolerability of Nasal Spray of Salmon Calcitonin in the Relief of Pain due to Bone Metastasis
Lee Soo-Yong

Jeon Dae-Geun
Lee Jong-Seok
Kim Sug-Jun
Hong Seok-Il
Choi Soo-Yong
Jang Jin-Dae
Abstract
Metastaic bone tumors are usually accompanied with severe pain. The treatment modalities for this pain are so variable that patients are sometimes afraid of using them. Salmon calcitonin has a func-tion to increase beta-endorphines followed by increasing the blood level of prostaglandic and throm-boxan A2,which results in analgesic effect. This drug also has been known to decrease bone resorption. There were a few reports that parenter-al use of salmon calcitonin decrease the pain from metastatic bone tumor. We wanted to know the effectiveness and tolerability of nasal spray of salmon calcitonin in relieving bone pain with metastat-ic tumor. We analyzed the effectiveness in the aspects of pain,sleep,performance status, mobility, supplementary analgesic use. The biologic effect of salmon calcitonin was analysed with CBC,Ca/P, BUN/Cr,uric acid. Simple radiography,alkaline phosphatase,osteocalcin,pyrilink-K were used as parameters for bone change. Eighteen cases of metastatic bone tumor took nasal spray of salmon calcitonin[Miacalcic,200IU/day] for 4 weeks, to relieve bone pain. With Wilcoxon Matched-pairs Signed Ranks Test,we could find pain decreased significantly at 3 week and monbility become improved at 4 week of salmon calcitonin use. Other parameters didn`t show any significant changes. We think the analgesic effect is mainly due to effect not on the local bone lesion but on the central nervous system,and that increased dose of salmon calcitonin can induce earlier and stronger anal-gesic effect.
KEYWORD
Bone pain, Metastatic bone tumor, Salmon calcitonin, Analgesic effect
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